Re2O Skin ReSet
ECM Booster

울세라 프라임

What is Re2O Skin ReSet ECM Booster?

Re2O Skin ReSet ECM Booster (Elravie Re2O) is a micronized human acellular dermal matrix (hADM) in powder form that provides extracellular matrix components to the skin. The treatment contains genuine ECM components derived from human skin tissue.

This treatment delivers skin components—collagen, elastin, hyaluronic acid, and other ECM proteins—directly into the dermal layer, where they integrate with existing tissue.

Re2O Skin ReSet ECM Booster functions as an ECM supplementation treatment, providing structural components to support the skin’s framework.

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The Technology Broken Down

Re2O Skin ReSet ECM Booster works through direct ECM supplementation by injecting human skin-derived components into the dermal layer, delivering a rich blend of essential ECM elements—including collagen (89%), elastin (3%), glycosaminoglycans (0.4%), and other structural proteins (7.6%)—to support and restore the skin’s natural framework.

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AlloClean™ Technology

This advanced processing method carefully minimizes DNA residues from human skin tissue while preserving the natural three-dimensional ECM structure, reducing the risk of immune reactions and ensuring biocompatibility.

This ensures the ECM components are safe, stable and ready to integrate with the skin’s natural framework.

INTEGRATION WITH TISSUE

Once injected, the ECM components integrate seamlessly with the existing skin structure. They interact with fibroblasts—the key cells that produce collagen and elastin—supporting the skin’s own regenerative processes.

This enhances the skin framework from within, promoting firmer, healthier, and more resilient skin over time.

Who is suitable for Re2O Skin ReSet ECM Booster?

This treatment is suitable for all skin types:

Concerns

The number of sessions required depends on your skin concern and its severity.

01

AGEING-RELATED

  • Fine lines & wrinkles
  • Loss of skin firmness
  • Reduced skin elasticity

02

Texture & Pores

  • Enlarged pores
  • Rough or uneven texture
  • Loss of skin density

03

PIGMENTATION

  • Post-Inflammatory Hyperpigmentation
  • Dull skin tone

04

SKIN REDNESS

  • Rosacea
  • Sensitive skin

05

Skin Health

  • Inflammation
  • Weakened Skin Barrier

06

Maintenance

  • Supporting ECM structure
  • General skin health

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WHAT AREAS CAN RE2O TREAT?

  • Loss of skin density without volume loss

  • Dull or fatigued-appearing skin

  • Post-inflammatory skin changes

  • Early laxity related to ECM weakening

  • Crepey under-eye texture

  • Thin, fragile skin

  • Reduced skin resilience

  • Crepey or thinning neck skin
  • Horizontal neck lines related to structural breakdown
  • Reduced skin elasticity
  • Sun-related skin changes

  • Uneven or rough skin texture

  • Skin affected by acne history or inflammation

  • Reduced skin firmness without volume deficiency

  • Skin stress from repeated procedures

  • Fine lines 

  • Thinning or weakened skin

  • Reduced skin resilience

  • Uneven skin texture

  • Fine lines and wrinkles

  • Chronic sun damage

  • Reduced skin density

  • Uneven texture and tone

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What is the Treatment Process Like?

Consultation & Pre-Treatment

First, your skin will be gently cleansed before a skin analysis is conducted. A thorough consultation with a registered medical professional will be done prior to any treatment.

Numbing

30 – 45 minutes of numbing is required before the treatment.

Treatment Process

The Re2O Skin ReSet ECM Booster is reconstituted and injected into targeted areas of the dermal layer.

After the treatment, a modelling mask or sheet mask may be applied.

Treatment Overview

Treatment area, duration, fequency of treatment and downtime.

Treatable Areas

Face, Neck

Duration

~2 hours

Frequency

Once a Month

Downtime

About 3 – 5 Days

FREQUENTLY ASKED QUESTIONS

Is Re20 the same as a skin booster?

No. Re2O belongs to the ECM category, which focuses on supporting the skin’s structural framework in the dermal layer. Unlike hydration-focused skin boosters, it is designed to complement your skin’s foundational support.

Learn more about ECM-focused injectables in our main Re2O Skin ReSet ECM Booster article.

Re2O Skin ReSet ECM Booster contains ECM-related proteins, including collagen, elastin, and glycosaminoglycans, rather than hyaluronic acid alone. This means it targets the skin’s structural framework instead of focusing solely on moisture delivery or temporary plumping effects.

Re2O Skin ReSet ECM Booster is delivered via micro-injections or an injector device into the dermal layer. Treatments are performed by trained practitioners, who determine the optimal injection technique and pattern based on individual skin needs.

ECM-based injectables are suitable for individuals interested in supporting overall skin quality and structural integrity. A personalised consultation is recommended to assess suitability based on skin type, medical history and aesthetic goals.

Re2O is placed in the dermal layer, where the extracellular matrix naturally exists. This deeper placement allows ECM components to interact directly with the skin’s structural proteins.

Yes. Skin ReSet ECM Booster can complement other treatments such as:

  • Hydration boosters — for moisture support

  • Neuromodulators or fillers — for expression or volume considerations

  • Energy-based devices — including RF microneedling, ultrasound, monopolar RF, or lasers

This allows for a layered, personalised treatment approach tailored to individual skin goals.

The number of sessions varies depending on skin condition, goals and practitioner recommendations. Some may notice subtle improvements after a single session, while others may follow a multi-session plan to support long-term skin quality.

During a consultation, a practitioner will:
  • Assess your skin condition and history
  • Discuss past treatments and lifestyle factors
  • Evaluate whether Re2O or other ECM-based options suit your goals
  • Recommend a personalised treatment plan
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No. Re2O complements other modalities but does not replace them. It targets the skin’s structural support, while other treatments focus on volume, hydration or surface-level concerns.

Downtime is generally minimal but varies depending on technique and individual response. Mild redness, swelling, or tenderness may occur and typically resolves within a few hours to a couple of days.

ECM-based injectables like Re2O work gradually. Subtle improvements may be noticed within a few weeks, but individual responses vary. The treatment is designed to support overall skin quality over time rather than deliver immediate, dramatic effects.

Yes. Re2O is made from purified human acellular dermal matrix and undergoes strict sourcing and processing standards. Treatments are administered by trained practitioners in clinical environments, ensuring safety and traceability. A personalised consultation determines suitability.

Treatment Pairings

Enhance your Skin ReSet ECM Booster by combining it with the following procedures to comprehensively address multiple concerns in a single session:

Volformer

Tightening • Volumising • Contouring

Pico Laser

Pigmentation • Melasma

Yellow Laser

Redness • Acne

5-Point Lifting injection

Hydration • Skin Laxity

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